CRF neurons in the ventral tegmental area control the aversive effects of nicotine withdrawal and promote escalation of nicotine intake
نویسندگان
چکیده
Taryn E. Grieder1, Melissa A. Herman2, Candice Contet2, Laura A. Tan4, Hector VargasPerez1, Ami Cohen2, Michal Chwalek1, Geith Maal-Bared1, John Freiling2, Joel E Schlosburg2, Laura Clarke1, Elena Crawford2, Pascale Koebel5, Vez Canonigo3, Pietro Sanna3, Andrew Tapper6, Marisa Roberto2, Brigitte L. Kieffer5,7, Paul E. Sawchenko4, George F. Koob8, Derek van der Kooy1, and Olivier George2 1Institute of Medical Science and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, M5S 3E1
منابع مشابه
Increased CRF signaling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal
Increased anxiety is a prominent withdrawal symptom in abstinent smokers, yet the neuroanatomical and molecular bases underlying it are unclear. Here we show that withdrawal-induced anxiety increases activity of neurons in the interpeduncular intermediate (IPI), a subregion of the interpeduncular nucleus (IPN). IPI activation during nicotine withdrawal was mediated by increased corticotropin re...
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